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Common Genetic Variant Linked to IVF Failure | Blog | County Pathology Ltd

Common Genetic Variant Linked to IVF Failure


A gene commonly found in women is strongly associated with abnormalities that can lead to the failure of in vitro fertilisation (IVF).
An analysis of embryos submitted for preimplantation genetic screening showed that the variant in the mother's genome appears to be linked to a gene responsible for abnormal rearrangements of chromosomes that occur during cellular replication, said Rajiv McCoy, PhD, a postdoctoral research fellow at the University of Washington in Seattle.

He presented the results at the American Society of Human Genetics 2015 Annual Meeting.

These abnormal rearrangements are common in 3-day-old blastomeres, but are rare in 5-day-old embryos, suggesting that the embryos that carry the aneuploidies do not survive. The presence of the genetic variant could explain why some women have particular difficulty with fertility, said Dr McCoy .

The investigators hypothesised that because "the first three embryonic cell divisions are controlled by maternal gene products deposited into the egg before the embryo's genome is actually turned on, or becomes active, variation in these maternal gene products might influence rates of aneuploidy in early embryos," he explained.